CloSed trial ( multicenter study CloSed FP7).  This study aimes to develop new guidelines for dosage regimen and drug formulation  of clonidine that can be used for sedation in neonates and children as well this study focuses on 1 year follow up therefore challenging is to be connected also with the follow up program and  follow up section as well. Our pharmacology section  and future direction will be to focus on the acute pharmacotherapy (individualized therapy) - should be also connected with other sections and will focus on long term outcome of diseases including pharmacotherapy  as newer future direction  (personalized pharmacotherapy).



Neubert A, Baarslag MA, van Dijk M, et al. The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial. BMJ Open. 2017;7(6):e016031. doi:10.1136/bmjopen-2017-016031.